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LISINOPRIL; HYDROCHLOROTHIAZIDE (Prinzide® or Zesteretic®) is a combination of two drugs used to lower blood pressure. Lisinopril is an ACE inhibitor that controls high blood pressure (hypertension) by relaxing blood vessels. Hydrochlorothiazide is a diuretic. High blood pressure can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. By lowering blood pressure, lisinopril-hydrochlorothiazide (Prinzide® or Zesteretic®) can help reduce your risk of having damage to your kidneys, heart, or other organs. This medicine does not cure high blood pressure. Generic lisinopril-hydrochlorothiazide (Prinzide® or Zesteretic®) tablets are available.
What should my health care professional know before I take lisinopril-hydrochlorothiazide (Prinzide® or Zesteretic®)?
They need to know if you have any of these conditions:
•autoimmune disease (e.g., lupus), or suppressed immune function
•previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat (angioedema)
•bone marrow disease
•diabetes mellitus
•gout
•heart or blood vessel disease
•liver disease
•recent heart attack or stroke
•kidney disease, (e.g. renal failure or renal artery stenosis)
•pancreatitis
•electrolyte imbalance (e.g. low or high levels of potassium in the blood)
•if you are on a special diet, such as a low-salt diet (e.g. using potassium substitutes)
•sulfonamide (sulfa) or thiazide allergy
•an unusual or allergic reaction to lisinopril, hydrochlorothiazide (Prinzide® or Zesteretic®), other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding
How
should I use this medicine (Prinzide® or Zesteretic®)?
Take lisinopril-hydrochlorothiazide (Prinzide® or Zesteretic®)tablets by mouth.
Follow the directions on the prescription label. You may take lisinopril-hydrochlorothiazide
(Prinzide® or Zesteretic®) with or without food. Swallow the tablets with a
drink of water. Take your doses at regular intervals. Do not take your medicine
more often than directed. Do not stop taking this medicine except on your
doctor's advice.
Many patients with high blood pressure will not notice any signs of the problem.
Therefore, it is very important that you take this medicine exactly as directed
and that you keep your appointments with your doctor or health care professional
even if you feel well. Contact your pediatrician or health care
professional regarding the use of this medicine in children. Special care may be
needed.
What
if I miss a dose (Prinzide® or Zesteretic®)?
If you miss a dose, take it as soon as you can. If it is almost time for your
next dose, take only that dose. Do not take double or extra doses.
What
drug(s) may interact with lisinopril-hydrochlorothiazide
(Prinzide® or Zesteretic®)?
•antiinflammatory drugs (NSAIDs, such as ibuprofen)
•cholestyramine
•colestipol
•dofetilide
•hawthorn
•lithium
•medicines for diabetes
•medicines for high blood pressure
•potassium salts or potassium supplements
•potassium-sparing diuretics (e.g., amiloride, triamterene)
Tell your prescriber or health care professional about all other medicines you
are taking, including nonprescription medicines, nutritional supplements, or
herbal products. Also tell your doctor or health care professional if you are a
frequent user of drinks with caffeine or alcohol, if you smoke, or if you use
illegal drugs. These may affect the way your medicine works. Check with your
health care professional before stopping or starting any of your medicines.
What
side effects may I notice from taking lisinopril-hydrochlorothiazide
(Prinzide® or Zesteretic®)?
Side effects that you should report to your doctor or health care professional
as soon as possible:
Rare or uncommon:
•difficulty breathing, difficulty swallowing, hoarseness, or tightening of the
throat
•redness, blistering, peeling or loosening of the skin, including inside the
mouth
•swelling of your face, lips, tongue, hands, or feet
•unusual rash, bleeding or bruising, or pinpoint red spots on the skin
Other:
•confusion, dizziness, lightheadedness or fainting spells
•decreased amount of urine passed
•decreased sexual function
•fast or uneven heart beat, palpitations, or chest pain
•fever or chills
•irregular heartbeat
•muscle cramps
•stomach pain
•vomiting
•unusual tiredness or weakness
•worsened gout pain
•yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your
doctor or health care professional if they continue or are bothersome):
•cough
•diarrhea
•headache
•increased sensitivity to the sun
•nausea
•tiredness or fatigue
What should
I watch for while taking lisinopril-hydrochlorothiazide
(Prinzide® or Zesteretic®)?
Check your blood pressure regularly while you are taking lisinopril-hydrochlorothiazide
(Prinzide® or Zesteretic®). Ask your doctor or health care professional what
your blood pressure should be and when you should contact him or her. When you
check your blood pressure, write down the measurements to show your doctor or
health care professional. You must not get dehydrated, ask your doctor or health
care professional how much fluid you need to drink a day. If you are taking this
medicine for a long time you must visit your doctor or health care professional
for regular checks on your progress. Make sure you schedule appointments on a
regular basis.
Check with your doctor or health care professional if you get an attack of
severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too
much body fluid can make it dangerous for you to take lisinopril-hydrochlorothiazide
(Prinzide® or Zesteretic®).
You may get dizzy. Do not drive, use machinery, or do anything that requires
mental alertness until you know how lisinopril-hydrochlorothiazide (Prinzide® or
Zesteretic®) affects you. To avoid dizzy or fainting spells, do not stand or sit
up quickly. Alcohol may increase the possibility of dizziness. Avoid alcoholic
drinks until you have discussed their use with your doctor or health care
professional.
If you are going to have surgery, tell your doctor or health care professional
that you are taking lisinopril-hydrochlorothiazide (Prinzide® or Zesteretic®).
Avoid salt substitutes unless you are told otherwise by your doctor or health
care professional. Do not take medicines for appetite control, asthma,
colds, cough, hay fever, or sinus problems without asking your doctor or health
care professional for advice. Do not treat yourself for a fever or sore throat;
check with your doctor or health care professional first. Lisinopril-hydrochlorothiazide
(Prinzide® or Zesteretic®) may affect your blood sugar level. If you have
diabetes, check with your doctor or health care professional before changing the
dose of your diabetic medicine.
Where
can I keep my medicine (Prinzide® or Zesteretic®)?
Keep out of the reach of children. Store at room temperature below 15—30
degrees C (59—86 degrees F). Protect from moisture and excessive light. Keep
container tightly closed. Throw away any unused medicine after the expiration
date.
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