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What are tamoxifen tablets?
TAMOXIFEN (Nolvadex®) blocks the effects of estrogen hormone in the body.
Tamoxifen is most commonly used to treat breast cancer in women or men. This
drug may reduce the chance of breast cancer coming back in women previously
treated with surgery, radiation, or chemotherapy. This drug may also help
prevent breast cancer in certain women with a high risk of developing breast
cancer. Occasionally this drug is used for other conditions. Generic tamoxifen
tablets are available.
What
should my health care professional know before I take tamoxifen?
They need to know if you have any of these conditions:
•blood clots
•blood disorders
•cataracts or impaired eyesight
•endometriosis, uterine fibroids
•high calcium levels
•high cholesterol
•irregular menstrual cycles
•an unusual or allergic reaction to tamoxifen, other medicines, foods, dyes, or
preservatives
•pregnant or trying to get pregnant
•breast-feeding
How
should I take this medicine?
Take tamoxifen tablets by mouth. Follow the directions on the prescription
label. Swallow the tablets with a drink of water. You may take tamoxifen with or
without food. Take your doses at regular intervals. Do not stop taking except on
your prescriber's advice.
Contact your pediatrician or health care professional regarding the use of this
medicine in children. Special care may be needed.What
if I miss a dose?
If you miss a dose, take it as soon as you remember, and then take the next dose
as usual. Do not take double or extra doses. If you vomit after taking a dose
call your prescriber or health care professional for advice.
What
drug(s) may interact with tamoxifen?
•aminogluthemide
•bosentan
•bromocriptine
•chemotherapy drugs
•cyclosporine
•delavirdine
•dietary supplements like black cohosh, chasteberry, melatonin, or soy
isoflavones
•efavirenz
•estrogen hormones, including some birth control products
•nevirapine
•protease inhibitors
•rifampin
•warfarin
Tell your prescriber or health care professional about all other medicines you
are taking, including nonprescription medicines, nutritional supplements, or
herbal products. Also, tell your doctor or health care professional if you are a
frequent user of drinks with caffeine or alcohol, if you smoke, or if you use
illegal drugs. These may affect the way your medicine works. Check with your
health care professional before stopping or starting any of your medicines.
What
side effects may I notice from taking tamoxifen?
Some side effects will only apply to women.
Side effects that you should report to your doctor or health care professional
as soon as possible:
•changes in your menstrual cycle
•changes in vaginal discharge
•changes in vision
•confusion
•difficulty walking or talking
•difficulty breathing
•excessive thirst
•new breast lumps
•numbness
•pelvic pain or pressure
•redness, blistering, peeling or loosening of the skin, including inside the
mouth
•shortness of breath
•skin rash
•swelling, pain or tenderness in your calf or leg
•swelling of lips, face, or tongue
•sudden chest pain
•unusual bruising or bleeding
•weakness
•vaginal bleeding
•yellowing of the whites of the eyes or skin
Side effects that usually do not require medical attention (report to your
doctor or health care professional if they continue or are bothersome):
•bone pain
•fatigue
•headache
•hair loss, although uncommon and is usually mild
•hot flashes
•impotence (in men)
•nausea, vomiting
•pain at tumor site
•weight loss
What should
I watch for while taking tamoxifen?
Visit your doctor or health care professional for regular checks on your
progress. You may need to have blood drawn to check your blood counts, calcium,
and/or cholesterol. Serious side effects to tamoxifen occur rarely. However, you
should contact your health care professional if you think you are having any
problems with your tamoxifen therapy. Some side effects of tamoxifen may occur
soon after starting the drug, but others may first appear at any time during
your treatment.
When you start taking tamoxifen to treat breast cancer, bone or tumor pain may
increase. This means that tamoxifen is working and the pain should soon
decrease. If the pain is severe, call your doctor or health care professional.
During this initial time, if you experience confusion or increased nausea,
thirst, urination, or vomiting call your health care professional immediately.
If you are taking tamoxifen to reduce your risk of getting breast cancer, you
should know that tamoxifen does not prevent all types of breast cancer. You
should have regular gynecological check-ups, including breast exams and
mammograms, and follow your doctor's recommendations. If breast cancer or other
problem occurs, there is no guarantee that it will be detected at an early
stage. This is why it is important to continue with regular check-ups. Women who
are or have taken tamoxifen should inform their doctor or health care
professional of any irregular menstrual cycles, abnormal vaginal bleeding,
changes in vaginal discharge, or pelvic pain or pressure.
Women should not become pregnant while taking tamoxifen or for 2 months after
tamoxifen therapy has stopped. You should see your doctor immediately if you
think you may have become pregnant while taking tamoxifen. Use of tamoxifen
early in pregnancy may harm your unborn child. Women who can have children
should use barrier birth control (condoms) or other methods of birth control
that do not use hormones. Talk with your health care provider for birth control
advice. Because tamoxifen may cause women to ovulate, it may increase the risk
of getting pregnant if appropriate birth control is not used.
Women who take tamoxifen are at increased risk for developing blood clots. Some
women may develop more than one clot, even if tamoxifen is stopped. If you
experience pain or swelling in your calves, sudden chest pain, shortness of
breath, or coughing up blood, call your doctor or health care professional right
away. Tamoxifen may increase the chance of having a stroke. If you experience
symptoms of a stroke such as weakness, difficulty walking or talking, or
numbness, contact your doctor immediately.
Tamoxifen may cause cataracts or changes to parts of the eye known as the cornea
or retina. If you experience any changes in your vision, including difficulty in
telling colors apart, tell your doctor or health care professional immediately.
Men who take tamoxifen may notice decreased sexual desire and impotence.
Where
can I keep my tamoxifen?
Keep out of the reach of children in a container that small children cannot
open. Store at room temperature between 15 and 30 degrees C (59 and 86
degrees F). Protect from light. Keep container tightly closed. Throw away any
unused medicine after the expiration date.
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