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What are carbidopa-levodopa tablets (Atamet®, Parcopa™,
Sinemet®)?
CARBIDOPA-LEVODOPA (Atamet®, Parcopa™, Sinemet®) is used to treat Parkinson's
disease. Levodopa (Atamet®, Parcopa™, Sinemet®) can help correct an imbalance of
chemicals in the brain caused by Parkinson's disease. Levodopa (Atamet®, Parcopa™,
Sinemet®)will not cure Parkinson's disease, but will help to control the
symptoms. Carbidopa helps levodopa work better, and this can decrease some side
effects, such as nausea. Generic carbidopa-levodopa (Atamet®, Parcopa™, Sinemet®)
tablets are available. Generic orally-disintegrating tablets are not yet
available.
What
should my health care professional know before I take carbidopa-levodopa? (Atamet®,
Parcopa™, Sinemet®)
They need to know if you have any of these conditions:
•asthma or lung disease
•depression or other mental illness
•diabetes
•glaucoma
•heart disease, including history of a heart attack
•irregular heart beat
•kidney disease
•liver disease
•melanoma or suspicious skin lesions
•seizure disorder
•stomach or intestinal ulcers
•an unusual or allergic reaction to levodopa, carbidopa (Atamet®, Parcopa™,
Sinemet®), other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding
How
should I take this medicine (Atamet®, Parcopa™,
Sinemet®)?
Take carbidopa-levodopa (Atamet®, Parcopa™, Sinemet®)tablets by mouth, refer to
the directions below that match the type of tablets you were prescribed. Follow
the directions on the prescription label. Take your doses at regular intervals.
Do not take your medicine more often than directed.
Atamet® or Sinemet® tablets or equivalent: Take tablets by mouth. Swallow the
tablets with a glass of water.
Parcopa™ tablets: These tablets are made to dissolve in the mouth without having
to take them with water. Place the tablet in the mouth and allow it to dissolve,
then swallow. While you may take these tablets with water, it is not necessary
to do so. Contact your pediatrician or health care professional regarding
the use of this medicine in children. Special care may be needed
What
if I miss a dose (Atamet®, Parcopa™, Sinemet®)?
If you miss a dose, take it as soon as you can. If it is less than 2 hours to
your next dose, take only that dose. Do not take double or extra doses. Try not
to miss a dose.
What
drug(s) may interact with carbidopa-levodopa (Atamet®,
Parcopa™, Sinemet®)?
•cocaine
•droperidol
•furazolidone
•isoniazid, INH
•iron supplements
•kava kava
•linezolid
•medicines for high blood pressure
•medicines for depression, avoid those called MAO inhibitors-phenelzine (Nardil®),
tranylcypromine (Parnate®), isocarboxazid (Marplan®)
•medicines for mental problems and psychotic disturbances
•metoclopramide
•papaverine
•phenytoin
•procarbazine
•s-adenosyl-l-methionine, SAM-e
•water pills
Tell your doctor or health care professional about all other medicines that you
are taking, including non-prescription medicines, nutritional supplements, or
herbal products. Also tell your doctor or health care professional if you are a
frequent user of drinks with caffeine or alcohol, if you smoke, or if you use
illegal drugs. These may affect the way your medicine works. Check with your
health care professional before stopping or starting any of your medicines.
What
side effects may I notice from taking carbidopa-levodopa
(Atamet®, Parcopa™, Sinemet®)?
Side effects that you should report to your doctor or health care professional
as soon as possible:
•difficulty passing urine
•dizziness, lightheadedness, or fainting spells
•fast or irregular heartbeat (palpitations)
•mental depression
•mood changes such as aggressive behavior or hallucinations
•stomach pain
•uncontrolled movements of the mouth, head, hands, feet, shoulders, eyelids or
other unusual muscle movements
Side effects that usually do not require medical attention (report to your
doctor or health care professional if they continue or are bothersome):
•anxiety, confusion, or nervousness
•dark color (brown, red, or black) of saliva, urine or sweat
•headache
•loss of appetite
•muscle twitches
•nausea/vomiting
•nightmares, trouble sleeping
•unusual tiredness or weakness
What should
I watch for while taking carbidopa-levodopa (Atamet®,
Parcopa™, Sinemet®)?
Visit your prescriber (Atamet®, Parcopa™, Sinemet®)or health care professional
for regular checks on your progress. It may be several weeks or months before
you feel the full benefits of carbidopa-levodopa (Atamet®, Parcopa™, Sinemet®).
Continue to take your medicine on a regular schedule and do not stop taking
except on your doctor's advice. Do not take any additional medicines for
Parkinson's disease without first consulting with your health care provider.
You may experience a "wearing off" effect prior to the time for your next dose
of carbidopa-levodopa (Atamet®, Parcopa™, Sinemet®). You may also experience an
"on-off" effect where the medicine apparently stops working for anything from a
minute to several hours, then suddenly starts working again. Tell your doctor or
health care professional if any of these symptoms happen to you, he/she may need
to adjust your dosage.
A high-protein diet can slow or prevent absorption of levodopa (Atamet®, Parcopa™,
Sinemet®). Avoid high protein foods near the time of taking carbidopa-levodopa
to help to prevent these problems. Take carbidopa-levodopa (Atamet®, Parcopa™,
Sinemet®)at least 30 minutes before eating or one hour after meals. You may want
to eat higher protein foods later in the day or in small amounts. Discuss your
diet with your doctor or health care professional or nutritionist.
Do not take iron supplements within 2 hours of taking levodopa (Atamet®, Parcopa™,
Sinemet®). The iron may decrease the amount of levodopa (Atamet®, Parcopa™,
Sinemet®) in your system and decrease the effectiveness of the drug
Do not sit or stand up quickly. This reduces the risk of dizzy or fainting
spells. The dizziness should decrease after taking carbidopa-levodopa (Atamet®,
Parcopa™, Sinemet®) for a couple of days. Alcohol can increase possible
dizziness; avoid alcoholic drinks.
If you are going to have surgery, tell your doctor or health care professional
that you are taking carbidopa-levodopa (Atamet®, Parcopa™, Sinemet®). If
you are diabetic, carbidopa-levodopa (Atamet®, Parcopa™, Sinemet®)may interfere
with the accuracy of some tests for sugar or ketones in the urine (does not
interfere with blood tests). Check with your doctor or health care professional
before changing the dose of your diabetic medicine. Carbidopa-levodopa (Atamet®,
Parcopa™, Sinemet®) may discolor the urine or sweat, making it look darker or
red in color; this is of no cause for concern. However, this may stain clothing
or fabrics.
Where
can I keep my medicine (Atamet®, Parcopa™, Sinemet®)?
Keep out of the reach of children in a container that small children cannot
open. Store at room temperature between 15° and 30°C (59° and 86°F).
Protect from light. Keep container tightly closed. Throw away any unused
medicine after the expiration date.
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