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CONJUGATED ESTROGENS (Premarin®, Cenestin™) contains a mixture of estrogen hormones. Estrogens are essential for maintaining normal female functions. Conjugated estrogens (Premarin®, Cenestin™) can help relieve symptoms of the menopause (hot flashes, night sweats, mood changes, and vaginal dryness and irritation), and also help to prevent osteoporosis (thin weak bones). Conjugated estrogens (Premarin®, Cenestin™) can also help improve female functions in women with hormonal imbalance or problems with their ovaries. This drug may also be given to patients with inoperable breast cancers (in men or women) or prostate cancer (men). Estrogens (Premarin®, Cenestin™) are occasionally prescribed for other purposes. Generic conjugated (Premarin®, Cenestin™) estrogen tablets are not yet available.
What should my health care professional know before I take conjugated estrogens(Premarin®, Cenestin™)?
They need to know if you have any of these conditions:
•asthma
•blood vessel disease, blood clotting disorder, or suffered a stroke
•breast, cervical, endometrial, ovarian or uterine cancer
•diabetes
•endometriosis
•fibroids in the womb
•heart disease
•high blood lipids or cholesterol
•high blood pressure
•high level of calcium in the blood
•low level of calcium in the blood
•hysterectomy
•kidney disease
•liver disease
•mental depression
•migraine
•porphyria
•thyroid disease
•tobacco smoker
•vaginal bleeding
•an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding
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How
should I take this medicine (Premarin®, Cenestin™)?
Take conjugated estrogen tablets by mouth. Follow the directions on the
prescription label. Swallow the tablet with a drink of water. Take the tablets
with food. Take your doses at regular intervals, at the same time each day. Do
not take your medicine more often than directed.
•For all uses of this medicine:
Before starting this medication, read the paper on your prescription provided by
your pharmacist or health care professional. This paper will tell you about the
specific product you are taking. Make certain you understand the instructions.
Contact your pediatrician or health care professional regarding the use of this
medicine in children. Special care may be needed.
What
if I miss a dose (Premarin®, Cenestin™)?
If you miss a dose, take it as soon as you can. If it is almost time for your
next dose, take only that dose. Do not take double or extra doses.
What
drug(s) may interact with conjugated estrogens ?(Premarin®,
Cenestin™)
•some antibiotics used to treat infections
•barbiturates or benzodiazepines used for inducing sleep or treating seizures
(convulsions)
•bromocriptine
•carbamazepine
•cimetidine
•cyclosporine
•dantrolene
•medications for diabetes
•methotrexate
•griseofulvin
•hydrocortisone, cortisone, or prednisolone
•isoniazid (INH)
•methotrexate
•mineral oil
•phenytoin
•raloxifene or tamoxifen
•rifabutin, rifampin, or rifapentine
•thyroid hormones
•topiramate
•tricyclic antidepressants
•warfarin
Tell your doctor or health care professional about all other medicines you are
taking, including non-prescription medicines, nutritional supplements, or herbal
products. Also tell your doctor or health care professional if you are a
frequent user of drinks with caffeine or alcohol, if you smoke, or if you use
illegal drugs. These may affect the way your medicine works. Check with your
health care professional before stopping or starting any of your medicines.
What
side effects may I notice from taking conjugated estrogens?
Side effects that you should report to your doctor or health care professional
as soon as possible:
•breakthrough bleeding and spotting
•breast enlargement, tenderness, unusual discharge or milk production
•chest pain
•confusion, forgetfulness
•leg, arm or groin pain
•nausea, vomiting
•severe headaches
•stomach pain (severe)
•sudden shortness of breath
•swelling of the hands, feet or ankles, or rapid weight gain
•vision or speech problems
•yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your
doctor or health care professional if they continue or are bothersome):
•change in sexual desire
•mild stomach upset
•mood changes, anxiety, depression, frustration, anger, or emotional outbursts
•increased or decreased appetite
•skin rash, acne, or brown spots on the face
•tiredness
•urinary incontinence
•vaginal yeast infection (irritation and white discharge)
•weight gain
What should
I watch for while taking conjugated estrogens (Premarin®,
Cenestin™)?
Visit your doctor or health care professional for regular checks on your
progress. You should have a complete check-up every 6 months. You will need a
regular breast and pelvic exam and 'Pap' smear while on conjugated estrogens
therapy. You should also discuss the need for regular mammograms with your
health care professional, and follow his or her guidelines for these tests.
Conjugated estrogens can make your body retain fluid, making your fingers,
hands, or ankles swell. Your blood pressure can go up. Contact your doctor or
health care professional if you feel you are retaining fluid. If you have
any reason to think you are pregnant; stop taking conjugated estrogens at once
and contact your doctor or health care professional.
Tobacco smoking increases the risk of getting a blood clot or having a stroke
while you are taking conjugated estrogens, especially if you are more than 35
years old. You are strongly advised not to smoke. If you wear contact
lenses and notice visual changes, or if the lenses begin to feel uncomfortable,
consult your eye care specialist or health care professional.
In women who still have their uterus, estrogens increase the risk of developing
a condition (endometrial hyperplasia) that may lead to cancer of the lining of
the uterus. Taking progestins (Premarin®, Cenestin™), another hormone drug, with
estrogens lowers the risk of developing this condition. Therefore, if your
uterus has not been removed (by a hysterectomy), your doctor may prescribe a
progestin for you to take together with your estrogen. You should know, however,
that taking estrogens with progestins (Premarin®, Cenestin™)may have additional
health risks. You should discuss the use of estrogens and progestins (Premarin®,
Cenestin™) with your health care professional to determine the benefits and
risks for you. If you are going to have elective surgery, you may need to
stop taking your estrogens one month beforehand. Consult your health care
professional for advice prior to scheduling the surgery.
Where
can I keep my medicine (Premarin®, Cenestin™)?
Keep out of the reach of children in a container that small children cannot
open. Store at room temperature between 15 and 30 degrees C (59 and 86
degrees F). Throw away any unused medicine after the expiration date.
Last Updated:06/05/2003
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