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What are
losartan-hydrochlorothiazide tablets (Hyzaar®)?
LOSARTAN-HYDROCHLOROTHIAZIDE (Hyzaar®) is a combination of two drugs
used to lower blood pressure. Losartan (Hyzaar®) controls high blood
pressure (hypertension) by relaxing blood vessels. Hydrochlorothiazide is a
diuretic. High blood pressure can damage the blood vessels of the brain, heart,
and kidneys, resulting in a stroke, heart failure, or kidney failure. By
lowering blood pressure, losartan-hydrochlorothiazide (Hyzaar®) can
help reduce your risk of having damage to your kidneys, heart, or other organs.
This medicine does not cure high blood pressure. Generic losartan-hydrochlorothiazide
(Hyzaar®) tablets are not yet available.
What should my
health care professional know before I take losartan-hydrochlorothiazide (Hyzaar®)?
They need to know if you have any of these conditions:
•autoimmune disease (e.g., lupus), or suppressed immune function
•diabetes mellitus
•gout
•heart or blood vessel disease (e.g. heart failure)
•liver disease
•recent heart attack or stroke
•kidney disease, (e.g. renal failure or renal artery stenosis)
•pancreatitis
•electrolyte imbalance (e.g. low or high levels of potassium in the blood)
•if you are on a special diet, such as a low-salt diet (e.g. using potassium
substitutes)
•sulfonamide (sulfa) or thiazide allergy
•an unusual or allergic reaction to losartan, hydrochlorothiazide (Hyzaar®),
other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding
How should I take
this medicine (Hyzaar®)?
Take losartan-hydrochlorothiazide (Hyzaar®) tablets by mouth.
Follow the directions on the prescription label. Swallow the tablets with a
drink of water. Losartan-hydrochlorothiazide (Hyzaar®) can be taken
with or without food. Take your doses at regular intervals. Do not take your
medicine more often than directed.
What if I miss a
dose (Hyzaar®)?
If you miss a dose, take it as soon as you can. If it is almost time for your
next dose, take only that dose. Do not take double or extra doses.
What drug(s) may
interact with losartan-hydrochlorothiazide (Hyzaar®)?
•allopurinol
•antiinflammatory drugs (NSAIDs, such as ibuprofen)
•blood pressure medicines
•bosentan
•delavirdine
•diabetic medications
•dofetilide
•fluconazole
•griseofulvin
•hawthorn or horse chestnut
•lithium
•potassium salts or potassium supplements
•prochlorperazine
•rifampin
•some antibiotics which increase sensitivity to sunlight (sulfonamides,
tetracyclines)
•some cholesterol-lowering medications (e.g. cholestyramine or colestipol)
•some medicines for mental disorders (phenothiazines)
•vitamin A (retinol) creams or pills such as tretinoin Retin-A®, Renova®, Solage®,
Atragen®, and others
•voriconazole
•water pills (especially potassium-sparing diuretics such as triamterene or
amiloride)
Tell your doctor or health care professional about all other medicines you are
taking, including nonprescription medicines, nutritional supplements, or herbal
products. Also tell your doctor or health care professional if you are a
frequent user of drinks with caffeine or alcohol, if you smoke, or if you use
illegal drugs. These may affect the way your medicine works. Check with your
health care professional before stopping or starting any of your medicines.
What side effects
may I notice from taking losartan-hydrochlorothiazide (Hyzaar®)?
Side effects that you should report to your doctor or health care professional
as soon as possible:
Rare or uncommon:
•difficulty breathing, difficulty swallowing, hoarseness, or tightening of the
throat
•redness, blistering, peeling or loosening of the skin, including inside the
mouth
•swelling of your face, lips, tongue, hands, or feet
•unusual rash, bleeding or bruising, or pinpoint red spots on the skin
Other:
•confusion, dizziness, lightheadedness or fainting spells
•decreased amount of urine passed
•decreased sexual function
•fast or uneven heart beat, palpitations, or chest pain
•fever or chills
•irregular heartbeat
•muscle cramps
•stomach pain
•vomiting
•unusual tiredness or weakness
•worsened gout pain
•yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your
doctor or health care professional if they continue or are bothersome):
•cough
•diarrhea
•headache
•increased sensitivity to the sun
•nausea
•tiredness or fatigue
What should I watch for
while taking losartan-hydrochlorothiazide (Hyzaar®)?
Check your blood pressure regularly while you are taking losartan-hydrochlorothiazide
(Hyzaar®). Ask your doctor or health care professional what your
blood pressure should be and when you should contact him or her. When you check
your blood pressure, write down the measurements to show your doctor or health
care professional. You must not get dehydrated. Ask your doctor or health care
professional how much fluid you need to drink a day. If you are taking this
medicine for a long time, you must visit your health care professional for
regular checks on your progress. Make sure you schedule appointments on a
regular basis.
Check with your doctor or health care professional if you get an attack of
severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too
much body fluid can make it dangerous for you to take losartan-hydrochlorothiazide
(Hyzaar®). You may get dizzy. Do not drive, use machinery, or
do anything that requires mental alertness until you know how losartan-hydrochlorothiazide
(Hyzaar®)affects you. To avoid dizzy or fainting spells, do not stand
or sit up quickly. Alcohol may increase the possibility of dizziness. Avoid
alcoholic drinks until you have discussed their use with your doctor or health
care professional. If you are going to have surgery tell your doctor or
health care professional that you are taking losartan-hydrochlorothiazide (Hyzaar®).
Losartan-hydrochlorothiazide (Hyzaar®) may affect your blood sugar
level. If you have diabetes, check with your doctor or health care professional
before changing the dose of your diabetic medicine. Avoid salt substitutes
unless you are told otherwise by your doctor or health care professional. Do not
take medicines for appetite control, asthma, colds, cough, hay fever, or sinus
problems without asking your doctor or health care professional for advice. Do
not treat yourself for a fever or sore throat; check with your doctor or health
care professional first.
Where can I keep
my medicine (Hyzaar®)?
Keep out of the reach of children in a container that small children cannot
open. Store at room temperature between 15 and 30 degrees C (59 and 86
degrees F). Protect from light. Keep container tightly closed. Throw away any
unused medicine after the expiration date.
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